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APRIL 15, 2010
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Raman Chemical Imaging - Shedding Light on Metered-Dose Inhalers with Multiple Active Pharmaceutical Ingredients
By Ryan J. Priore, Ph.D.
In today’s pharmaceutical market, the reach of respiratory drugs and associated delivery technologies is expanding due to their potential to increase drug uptake rates and improve bioavailability for certain drugs (relative to oral dosing), as well as their convenient administration. Most often limited to localized diseases (e.g. rhinitis), recent research and development activities of inhalable products point to opportunities in nontraditional therapeutic areas like motion sickness and seizures. As a result, the need to develop rapid, cost-effective methods of generating particle analysis data for active pharmaceutical ingredients (APIs) in pulmonary formulations is on the rise.
All Particles Are Not Created Equal
In pulmonary drug delivery, the drug particle size will determine the rate of dissolution, dosage and availability to sites of action within the lungs. With that in mind, particle size distribution (PSD) for the drug or drug aggregates should be characterized in the formulated product both within the primary container and within the aerosolised droplets. Aggregation between API and excipient ingredients bring about an increase in overall particle size and may cause a number of potential problems like changes in bioavailability and/or clogging of the delivery device.
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Upcoming Trade Shows
From conferences covering respiratory drugs to particle technology, ChemImage will be exhibiting at several meetings this spring, including:
Respiratory Drug Delivery 2010 Conference
April 25-29, 2010; Orlando, Fla.
> Learn more about what we are doing at the show!
MERCK Technology Symposium and Trade Show
May 12-13, 2010; Long Branch, N.J.
Particles 2010
May 22-25, 2010; Lake Buena Vista, Fla.
ChemImage frequently exhibits at and/or attends a wide variety of national trade
shows and would welcome the opportunity to discuss our wide range of chemical
imaging solutions with you in person. To find out more about what we are doing
at these events, visit our events calendar.
ChemImage Issued 100th Patent
April 6 marked an important achievement in our company history—the issuance of our 100th U.S. patent, number 7,692,776 for a chemical imaging explosives optical sensor that detects explosive compounds.
Over the past 16 years, ChemImage has invested substantial resources in building a robust patent portfolio, including patents for chemical imaging instrumentation, image analysis, threat detection, forensics tools, pharmaceutical analysis, particle sizing and biomedical diagnostics.
> Read Full Press Release
Resources
Below are some related resources that are available for download.
- NEW! Video tutorial: Measuring Coating Thickness of Controlled Release Bead Using Raman Chemical Imaging
- NEW! ONdrugDelivery magazine publication: Ingredient-specific particle sizing: reducing risk, cutting cost and saving time in preclinical inhalable formulation development
- NEW! Drug Discovery & Development magazine publication: Ensuring Bead Uniformity
- Video tutorial: Ingredient-Specific Particle Sizing Overview
- Application note: Identification of Drug Forms in Solid Solutions Using Wide-field Raman Chemical Imaging
- Academic poster: Automation of Ingredient-Specific Particle Sizing Employing Raman Chemical Imaging
Additional resources are available on our web site: video tutorials, posters, application notes and publications.
To request more information on any topic, please contact us.
Pharma Focus is published by ChemImage Corporation.© ChemImage Corporation 2010. All rights reserved.