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Ingredient-Specific Particle Sizing Laboratory Services

ChemImage now offers ingredient-specific particle sizing laboratory services. This is an ideal way to evaluate Chemical Imaging technology and help build your case for integration of this technology in your organization. Use our services to extend your own laboratory capabilities and capacity by outsourcing your imaging needs to our experienced imaging experts.

ChemImage conducts on-going studies using the FALCON II™ Wide-Field Raman Chemical Imaging System to determine chemical identity and particle size distribution (PSD) of micronized drug substances in aqueous suspension nasal spray formulations. These studies are performed in collaboration with the FDA with the long-term goal of establishing a fully validated in vitro particle sizing method for measuring bioequivalence of nasal drug delivery products or batch comparison.

Wide-field Raman Chemical Imaging:

  • Distinguishes API in formulated products
  • Counts and measures only API particles
  • Confirms particle identity with Raman spectra

The FALCON II System is able to differentiate between and identify the chemical makeup of multiple components in complex mixtures. API particles are clearly distinguishable from those of excipients where RCI displays both solitary and aggregated API particles.

FALCON II efficiently collects millions of spectrally unique data points at sub-micron spatial resolution. Acquisition rates surpass the speed of competing point and line mapping systems. The substantial time and labor savings are ultimately transformed into cost savings and a reduced time to market. For more details, please refer to: Doub, W.H. et al. (2007), “Raman Chemical Imaging for Ingredient-Specific Particle Size Characterization of Aqueous Suspension Nasal Spray Formulations,” Pharm. Research, Vol 24, No 12, pp 304-345.

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To Contact Us About Our Laboratory Services

Use our rapid web response form to request more information and to have a ChemImage sales representative contact you.
You can also contact us directly at:

ChemImage Corp.
7301 Penn Avenue
Pittsburgh, PA 15208
Phone: 412.241.7335
Fax: 412.241.7311
Email: info@chemimage.com

 




FALCON II™

The ChemImage FalconIIThis system combines wide-field Chemical Imaging with dispersive Raman spectroscopy, for a wide range of chemical analysis needs.


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Posters

Raman Chemical Imaging for Drugs and Excipients in Aqueous Suspension Nasal Spray Formulations (PDF 360 KB)

Raman Chemical Imaging as a Tool for the Ingredient-Specific Particle Size Characterization of Aqueous Suspension Formulations of Nasal Sprays (PDF 524 KB)

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Application Note

Measuring Ingredient-Specific Particle Size Distribution Using Wide-Field Raman Chemical Imaging (PDF 456 KB)
* Work performed in collaboration with the U.S. Food and Drug Administration