Chemical Imaging Resources
Knowledge—general, technical and from hard-earned results in the field—is what drives the ChemImage family of products and solutions. Here you’ll find active links to available chemical imaging product information, corporate capabilities, brochures, technical specifications and more.
Home / Resources / Application Notes
Sometimes it’s tough to envision the applicability of ChemImage technology outside the laboratory or field environment. The following collection of scenario notes contain revealing, real-world discussions about Chemical Imaging applications across the pharmaceutical, biomedical and forensic industries.
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Analyzing Pharmaceutical Tablet Architecture Using Wide-Field Raman Chemical Imaging and Multivariate Image Processing (PDF 292 KB)
Raman spectroscopy is an efficient, non destructive way for probing molecular composition and structure of pharmaceutical tablets as well as quantization. However, bulk spectroscopy is ineffective for measuring the heterogeneous distribution of active ingredients within tablets. Wide-field Raman Chemical Imaging is a powerful technique for the analysis of pharmaceutical tablet architecture.
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Imaging of Polymer and Drug Polymer Delivery Systems Using Wide-Field Raman Chemical Imaging (PDF 576 KB)
An array of stent technologies has been developed over the past 15-20 years in an effort to prevent arterial restenosis (i.e., reclosure). The latest of these stent technologies, drug-eluting stents, are metal scaffold devices coated with a pharmacological agent. |
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Monitoring Droplet Size Distribution Using Wide-Field Raman Chemical Imaging (PDF 250 KB)
Monitoring droplet size of the internal phase of emulsion products is critical for manufacturers of these products because droplet size affects the stability, chemical reactivity and bioavailability of the ingredients. |
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Measuring Ingredient-Specific Particle Size Distribution Using Wide-Field Raman Chemical Imaging (PDF 456 KB)
* Work performed in collaboration with the U.S. Food and Drug Administration
Intranasal drug delivery is an attractive delivery method for a broad range of pharmaceuticals that treat a variety of diseases. This patient-friendly delivery method can provide multiple benefits including faster onset, reduction in potential side effects and increased compliance of the drug treatment. |
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Nondestructive Analysis of Ingredient Blend Uniformity in Pharmaceutical Tablets Using Wide-Field Raman Chemical Imaging (PDF 306 KB)
Product quality is critical in pharmaceutical manufacturing. Changes in drug properties during formulation scale-up and manufacturing can adversely affect product performance. |
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Nondestructive Analysis of Ingredient Distribution and Heterogeneity in Pharmaceutical Tablets Using Wide-Field Near Infrared Reflectance Chemical Imaging (PDF 186 KB)
Wide-field near infrared (NIR) Chemical Imaging provides high throughput assessment of composition heterogeneity and active ingredient distribution in pharmaceutical tablet formulations. Understanding tablet uniformity and ingredient distribution is critical to tablet quality monitoring and control. |
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Studying Controlled Release Mechanisms Using Wide-Field Raman Chemical Imaging
(PDF 181 KB)
A controlled release device is a complex system designed to efficiently deliver an accurate dosage of a drug to the targeted tissue. Wide-field Raman Chemical Imaging (RCI) facilitates a better understanding of the manufacturing process for improved product performance. |
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Characterization of Complex Pharmaceutical Mixtures Using Wide-Field Raman Chemical Imaging (PDF 239 KB)
Pharmaceutical companies closely monitor their productio process observing chemical structures, intermediates and side products. Rapid acquisition, interpretation and analysis are crucial for effcient process optimization. Examining selected stages of manufacturing may become routine with wide-field Raman Chemical Imaging. |
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Polymorph Identification and Discrimination Using Wide-Field Raman Chemical Imaging
(PDF 210 KB)
Enabling polymorph discovery at an early stage of the drug development process is critical to the pharmaceutical industry. Polymorphism can affect efficacy, bioavailability and the shelf life of a pharmaceutical drug. Wide-field Raman Chemical Imaging facilitates fast screening of polymorphic forms to increase quality, safety and efficacy of drug products. |