Chemical Imaging Resources
Knowledge—general, technical and from hard-earned results in the field—is what drives the ChemImage family of products and solutions. Here you’ll find active links to available chemical imaging product information, corporate capabilities, brochures, technical specifications and more.
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The content available in this section includes full-color posters and abstracts of experiments that run the gamut of ChemImage solutions—from pharmaceutical and biomedical advances, to forensic analysis studies and dramatic discoveries in bio-threat and bio-hazard detection.
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Biotechnology Problem Solving using Molecular Chemical Imaging (PDF 1 MB)
Within the pharmaceutical industry, Raman chemical imaging (RCI) technology is being used to assess aqueous nasal suspension formulations. In this application, RCI shows promise as a means for characterizing particle size of active drug ingredients. RCI may represent a future strategy for in vitro assessment of bioequivalence (manuscript in preparation in collaboration with the FDA).
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Experimental Parameter Tradeoffs in High Throughput Polymorph and Salt Screening
(PDF 1.1 MB)
Chemical Imaging combines molecular spectroscopy and digital imaging, and has been demonstrated to be a powerful tool for molecular analysis of a wide range of materials. Chemical Imaging provides molecular, compositional and structural information, without the use of dyes or stains. Because Chemical Imaging is based on optical spectroscopy, it operates rapidly, in a non-contact, noninvasive sampling mode. As a result, Chemical Imaging is an excellent candidate technique for high throughput screening. |
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The potential use of Raman imaging for determination of the particle size distribution (PSD) of active pharmaceutical ingredients (APIs) in metered-dose inhalers (PDF 834 KB)
Raman microscopic imaging is a powerful tool for differentiating formulation components and, potentially, chemical quantitation. It is a possible candidate to replace cascade impaction as a tool to determine chemical identity and particle size distribution (PSD). |
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Polymorphic Discrimination during Crystallization from a Room Temperature Acetaminophen Glass using Raman Chemical Imaging (PDF 284 KB)
The purpose of this study is to characterize the transformation from amorphous and crystalline acetaminophen (APAP) with polymorphic resolution using Raman chemical imaging. |
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Quantitative Assessment of Raman Molecular Chemical Imaging Performance Using a Reference Material (PDF 891 KB)
Raman molecular chemical imaging combines molecular spectroscopy and digital imaging, and is becoming a widely used analysis method for generating molecular-specific image contrast on complex, multicomponent materials. As Raman imaging matures, there is a developing need for costeffective standard reference materials (SRMs) suitable for objective assessmentn of Raman imaging sensor performance. |
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Raman Chemical Imaging for Drugs and Excipients in Aqueous Suspension Nasal Spray Formulations (PDF 360 KB)
Interest in nasal delivery of pharmaceutical products is increasing due to the potential for increased drug uptake rates and improved bioavailability for certain drugs relative to oral dosing, the convenience of nasal delivery and the development of new delivery platforms that may modify distribution in the nose. In this study we investigated the use of Raman chemical imaging (RCI) along with brightfield reflective imaging to measure particle size, chemical identity, particle associations and particle size distributions (PSDs) of corticosteroids in an aqueous nasalspray suspension product. |
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Raman Chemical Imaging as a Tool for the Ingredient-Specific Particle Size Characterization of Aqueous Suspension Formulations of Nasal Sprays (PDF 524 KB)
Interest in nasal delivery of pharmaceutical products is increasing due to the potential for increased drug uptake rates and improved bioavailability for certain drugs relative to oral dosing, the convenience of nasal delivery and the development of new delivery platforms that may modify distribution in the nose. In this study we investigated the use of Raman chemical imaging (RCI) along with brightfield reflective imaging to measure particle size, chemical identity, particle associations and particle size distributions (PSDs) of corticosteroids in an aqueous nasalspray suspension product. |
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Raman Chemical Imaging of Complex Pharmaceutical Products (PDF 193 KB)
Molecular chemical imaging combines molecular spectroscopy with digital imaging to provide high-quality chemical information in a visually rich, informative way. The improvements in speed and quality of material characterization enabled by molecular chemical imaging have driven the adoption of chemical imaging technology for detecting and visualizing active ingredient compounds in complex pharmaceutical product mixtures. |
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Raman Chemical Imaging of Type II Acetaminophen Crystallized from Aqueous Solution
(PDF 758 KB)
Purpose: To use Raman chemical imaging to guide method development for crystallizing orthorhombic acetaminophen (APAP) from unseeded aqueous solution. |
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Volumetric Widefield Raman Chemical Imaging (PDF 282 KB)
Chemical Imaging is a powerful analytical tool combining molecular spectroscopy and digital imaging for rapid visualization of material compositional heterogeneity. The dramatic improvements in speed and quality of material characterization guide the adoption of Chemical Imaging technology as an analytical tool. |