ChemImage is developing intraoperative endoscope technology for reagentless detection of tumor margins and tissue anatomic structures in real-time and in the presence of obscuration during surgical procedures.

Broadly applicable to all types of minimally invasive and robotic surgeries, ChemImage molecular chemical imaging technology provides:

  • Real-time imaging without the use of contrast agents
  • Tissue anatomic structure visualization and detection during endoscopic guided surgery
  • Tumor margin detection

Molecular chemical imaging (MCI) provides advanced visualization without contrast agents – in real-time. When validated in humans, it has the potential to reduce surgical time, patient risk, and the need for repeat surgeries. The following videos demonstrate reagentless, real-time in vivo visualization and detection of anatomical structures during pre-clinical studies.

Uterine Artery

Real time visualization and detection of an uterine artery during surgery. MCI detection video shown on right.

Abdominal Artery

Real time visualization and detection of an abdominal artery during surgery. MCI detection video shown on right.

Abdominal Vein

Real time visualization and detection of an abdominal vein during surgery. MCI detection video shown on right.

Bowel Perfusion

Real time visualization and detection of bowel perfusion during surgery showing ischemic bowel vs well perfused bowel detected in green. MCI detection video shown on right.

Ureter & Vein

Simultaneous, multi-target, real-time visualization and detection of obscured ureter (green) and vein (blue) during surgery. MCI detection video shown on right.

Partially Exposed Ureter

Real time visualization and detection of partially exposed ureter during surgery. MCI detection video shown on right.

Ureter 10 FPS

Real time visualization and detection of exposed ureter during surgery at 10 frames per second (FPS). MCI detection video shown on right.

Ureter 28 FPS

Real time visualization and detection of exposed ureter during surgery at 28 frames per second (FPS). MCI detection video shown on right.

Lymph Node

Real time visualization and detection of lymph node during surgery. MCI detection video shown on right.

Thyroid

Real time visualization and detection of thyroid during surgery. MCI detection video shown on right.

Laryngeal Nerve

Real time visualization and detection of laryngeal nerve during surgery. MCI detection video shown on right.

Prostate Nerve & Neurovascular Bundle

Simultaneous multi-target visualization and detection of prostate nerve and neurovascular bundle. MCI detection video shown on right.

The ChemImage MCI technology platform provides surgeons a greater awareness of what is happening inside the body while performing surgery, which is an important unmet clinical need. Recent pre-clinical in vivo testing showed successful visualization and discrimination of lymph nodes, ureters, vessels, nerves and tissue perfusion versus tissue backgrounds, under relevant surgical conditions. In the videos above, ChemImage has demonstrated real-time in vivo visualization and detection of:

  • Blood vessels (arteries and veins) and tissue perfusion;
  • Obscured and exposed ureter, including at 28 frames per second;
  • Lymph nodes, thyroid tissue and laryngeal nerve;
  • Simultaneous multi-target detection of prostate nerves and neurovascular bundle;

MCI technology is the first of its kind for reagentless, real-time visualization and detection of anatomic structures without the use of dyes, and these pre-clinical studies represent an important milestone in the development and validation of our technology platform.

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